HOMA-IR Calculator (HOMA1)
Calculate the HOMA1-IR index from fasting insulin and fasting glucose.
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HOMA-IR (HOMA1)
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Derived fasting index; no universal diagnostic cutoff is applied
Normalized glucose: — mg/dL (— mmol/L)
About
HOMA-IR is a research-oriented index derived from fasting insulin and fasting glucose. This page implements the original HOMA1 arithmetic in conventional or SI glucose units. Assay methods, population distributions, fasting conditions, and the distinction between HOMA1 and the computer-based HOMA2 model all matter when interpreting the value.
Formula
Interpretation
Units: Fasting insulin is entered in µU/mL (numerically equivalent to mIU/L). Glucose can be entered in mg/dL or mmol/L and is normalized before calculation.
Worked example: Fasting insulin 10 µU/mL and glucose 90 mg/dL gives HOMA-IR = 10 × 90 ÷ 405 = 2.22.
Limitations: There is no universal stand-alone cutoff across assays and populations. Acute illness, medications, beta-cell function, fasting quality, and insulin assay calibration affect the result. This calculation does not diagnose insulin resistance or diabetes.
References
- Matthews DR, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419.
- Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care. 1998;21:2191-2192.
FAQ
Disclaimer
Educational and informational reference only. Not intended to replace professional medical advice, diagnosis, treatment, or independent verification.