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HematologyTSAT

Transferrin Saturation Calculator (TSAT)

Calculate transferrin saturation from serum iron and TIBC.

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Transferrin saturation

Calculated iron-binding percentage; no diagnostic category is assigned

About

Transferrin saturation (TSAT) estimates the percentage of total iron-binding capacity occupied by serum iron. This version uses directly reported serum iron and TIBC only.

Formula

Transferrin saturation (%) = serum iron ÷ TIBC × 100

Interpretation

What the result represents: A calculated percentage relating serum iron to total iron-binding capacity.

Input units: Serum iron and TIBC may each use µg/dL or µmol/L; both are converted with the iron molar mass before division.

Worked example: Serum iron 100 µg/dL and TIBC 300 µg/dL gives 33.3%.

Applicable population: Laboratory reference use when serum iron and directly measured or laboratory-reported TIBC are available.

Interpretation limitations: Collection timing, fasting status, inflammation, liver function, transferrin concentration, and assay method can affect results. TSAT alone does not establish iron deficiency, iron overload, or hereditary hemochromatosis and does not select iron therapy or phlebotomy.

References

  1. MedlinePlus. Iron Tests and Total Iron-Binding Capacity.
  2. Bacon BR, et al. AASLD Practice Guideline: Diagnosis and Management of Hemochromatosis. Hepatology. 2011.

FAQ

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Disclaimer

Educational and informational reference only. Not intended to replace professional medical advice, diagnosis, treatment, or independent verification.