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Sodium Correction for Hyperglycemia

Input

mEq/L
mg/dL

Corrected Na⁺ (Katz)

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Corrected Na⁺ (Hillier)

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About

In hyperglycemia, water shifts from intracellular to extracellular space due to the osmotic effect of glucose, diluting serum sodium. The corrected sodium estimates what the sodium level would be if glucose were normal. This is important for assessing true sodium status in patients with diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS).

Formula

Katz (1973): Corrected Na = Measured Na + 1.6 × [(Glucose − 100) / 100]
Hillier (1999): Corrected Na = Measured Na + 2.4 × [(Glucose − 100) / 100]
Glucose in mg/dL. The Hillier formula may be more accurate at very high glucose levels.

Interpretation

Corrected Na (mEq/L)Interpretation
< 135Hyponatremia
135 – 145Normal
> 145Hypernatremia

References

  1. Katz MA. Hyperglycemia-induced hyponatremia — calculation of expected serum sodium depression. N Engl J Med. 1973;289(16):843-844.
  2. Hillier TA, et al. Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med. 1999;106(4):399-403.

FAQ

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Disclaimer

For educational and informational purposes only. Not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional.