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EndocrinologyHbA1c

HbA1c Calculator (A1c to eAG)

Convert HbA1c between NGSP percent and IFCC mmol/mol units and estimate average glucose in mg/dL and mmol/L using the ADAG equation, with diagnostic and assay limitations.

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Formula and medical content are based on the references listed on this page. See sources, About, and Sources and Review Process.

Select the unit printed on the laboratory report.

Calculator input guardrails are 2.0–20.0% NGSP or 0–195 mmol/mol IFCC; these are technical limits, not healthy, normal or treatment ranges.

About

HbA1c is an indirect marker of average glycemia over approximately the prior 2–3 months, with recent weeks contributing more heavily. This page uses the 2008 ADAG regression derived from 507 adults and extensive intermittent CGM and fingerstick glucose data to translate A1C into eAG. eAG is not a directly measured mean glucose and can differ from modern CGM mean glucose or glucose management indicator (GMI); A1C also does not show glucose variability or hypoglycemia. HbA1c may be used in appropriate nonpregnant screening or diagnostic contexts and to monitor established diabetes, but it cannot determine diabetes type or independently diagnose gestational diabetes. Diagnosis requires an appropriate certified laboratory method and confirmation when indicated, while treatment goals must be individualized. Altered hemoglobin, red-cell lifespan, pregnancy, disease and treatment effects can make A1C falsely high or low.

Formula

eAG (mg/dL) = 28.7 × HbA1c (NGSP %) − 46.7.
eAG (mmol/L) = 1.5944 × HbA1c (NGSP %) − 2.594.
IFCC (mmol/mol) = 10.93 × NGSP (%) − 23.50.
NGSP (%) = 0.09148 × IFCC (mmol/mol) + 2.152.

Interpretation

What HbA1c and eAG represent

A1C indirectly reflects glycation across red-cell survival over roughly 2–3 months, with greater weight from recent weeks. eAG is a regression translation from the ADAG study, not a glucose measured at the same time. Neither A1C nor eAG shows daily variability, post-meal peaks or hypoglycemia.

ADA diagnostic context for nonpregnant individuals

Below 5.7% NGSP or 39 mmol/mol IFCC is below the prediabetes threshold; 5.7–6.4% or 39–47 mmol/mol is the prediabetes range; and at least 6.5% or 48 mmol/mol is the diabetes diagnostic threshold. These thresholds require the appropriate clinical context and an NGSP-certified, DCCT-traceable laboratory method. In the absence of unequivocal hyperglycemia, diagnosis generally requires confirmatory testing. This page cannot establish a diagnosis.

Monitoring goals are individualized

ADA 2026 describes an A1C goal below 7% as appropriate for many nonpregnant adults, not everyone. Lower or less stringent goals depend on hypoglycemia risk, age, functional status, comorbidities, life expectancy, treatment burden and personal goals. This page does not recommend treatment changes.

A1C, CGM and measured glucose are different

A1C is indirect, and eAG comes from one 2008 study. Modern CGM mean glucose, GMI and eAG may differ. A1C does not report time in range, time below range, time above range or glycemic variability. BGM or CGM context is particularly important with insulin therapy or marked glucose variability.

Conditions that alter A1C interpretation

Hemolytic anemia, iron-deficiency anemia, acute or recent blood loss, transfusion, erythropoietin or other erythropoiesis-stimulating therapy, kidney failure or hemodialysis, pregnancy, G6PD deficiency, HIV, liver disease and hemoglobin variants can alter interpretation. HbSS, HbCC, HbSC and other states without normal HbA require particular caution. Results may be falsely high or low depending on red-cell biology and the assay-specific interference.

What to do when results disagree

A marked mismatch between A1C and glucose or CGM should prompt investigation of interference, the laboratory method and hemoglobin variants. Plasma-glucose diagnostic criteria may be appropriate for diagnosis; BGM, CGM, fructosamine or glycated albumin may help monitoring in selected contexts. This page does not choose a substitute test or treatment.

References

  1. Nathan DM, et al. Translating the A1C assay into estimated average glucose values. Diabetes Care. 2008;31(8):1473–1478. PMID 18540046. PMCID PMC2742903. DOI 10.2337/dc08-0545.
  2. American Diabetes Association Professional Practice Committee for Diabetes. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026. Diabetes Care. 2026;49(Suppl 1):S27–S49. PMID 41358893. PMCID PMC12690183. DOI 10.2337/dc26-S002.
  3. American Diabetes Association Professional Practice Committee for Diabetes. 6. Glycemic Goals, Hypoglycemia, and Hyperglycemic Crises: Standards of Care in Diabetes—2026. Diabetes Care. 2026;49(Suppl 1):S132–S149. PMID 41358894. PMCID PMC12690178. DOI 10.2337/dc26-S006.
  4. National Glycohemoglobin Standardization Program. HbA1c and Estimated Average Glucose (eAG).
  5. National Glycohemoglobin Standardization Program. IFCC Standardization of HbA1c.
  6. National Glycohemoglobin Standardization Program. Factors that Interfere with HbA1c Test Results.
  7. National Institute of Diabetes and Digestive and Kidney Diseases. The A1C Test & Diabetes.
  8. National Institute of Diabetes and Digestive and Kidney Diseases. Sickle Cell Trait & Other Hemoglobinopathies & Diabetes.

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Disclaimer

Educational and informational reference only. Not intended to replace professional medical advice, diagnosis, treatment, or independent verification.