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Urine Protein-Creatinine Ratio (UPCR)

Input

mg/dL
mg/dL

UPCR

Estimated 24hr Protein

About

The Urine Protein-to-Creatinine Ratio (UPCR) estimates 24-hour urine protein excretion from a spot urine sample. It avoids the inconvenience of 24-hour urine collection. A UPCR > 3.5 mg/mg indicates nephrotic range proteinuria. The UPCR correlates well with 24-hour protein excretion and is recommended by KDIGO for monitoring proteinuria in CKD patients.

Formula

UPCR (mg/mg) = Urine Protein (mg/dL) / Urine Creatinine (mg/dL)
Estimated 24hr protein (mg/day) ≈ UPCR × 1000

Interpretation

UPCR (mg/mg)~24hr ProteinInterpretation
< 0.15< 150 mg/dayNormal
0.15 – 0.5150–500 mg/dayMild proteinuria
0.5 – 3.5500–3500 mg/dayModerate proteinuria
> 3.5> 3500 mg/dayNephrotic range

References

  1. Ginsberg JM, et al. Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med. 1983;309(25):1543-1546.
  2. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013;3(1):1-150.

FAQ

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Disclaimer

For educational and informational purposes only. Not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional.