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Albumin-Corrected Anion Gap
Input
mEq/L
mEq/L
mEq/L
g/dL
Anion Gap
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Albumin-Corrected Anion Gap
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About
The Albumin-Corrected Anion Gap adjusts the standard anion gap for hypoalbuminemia, which is common in hospitalized patients. Each 1 g/dL decrease in albumin below 4.0 g/dL reduces the anion gap by approximately 2.5 mEq/L, potentially masking an elevated anion gap acidosis. The Delta-Delta ratio (Delta Gap) further classifies mixed acid-base disorders by comparing the change in anion gap to the change in bicarbonate.
Formula
Anion Gap (AG) = Na − (Cl + HCO₃)
Corrected AG = AG + 2.5 × (4.0 − Albumin)
Delta-Delta = (Corrected AG − 12) / (24 − HCO₃)
Interpretation
| Parameter | Interpretation |
|---|---|
| Corrected AG ≤ 12 | Normal anion gap |
| Corrected AG > 12 | Anion gap metabolic acidosis |
| Delta-Delta < 1 | Concurrent non-AG metabolic acidosis |
| Delta-Delta 1 – 2 | Pure AG metabolic acidosis |
| Delta-Delta > 2 | Concurrent metabolic alkalosis |
FAQ
Disclaimer
For educational and informational purposes only. Not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional.